SJB3-019A
Catalog No.
B1307
Usp1 inhibitor
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SJB3-019A is a small-molecule inhibitor targeting ubiquitin-specific protease 1 (USP1). USP1 is a deubiquitinating enzyme involved in protein ubiquitination(ID1).SJB3-019A supresses USP1-mediated deubiquitination, thereby regulating the degradation of key substrates such as inhibitor of DNA binding 1. In cell-based studies, SJB3-019A demonstrates cytotoxicity and promotes ID1 protein degradation, with an IC50 value of 0.0781 μM in K562 leukemia cells.SJB3-019A holds research potential in investigating USP1-regulated pathways in cancer biology and DNA repair processes.
Reference:
[1]. Mistry H, Hsieh G, Buhrlage SJ, et al. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther, 2013, 12(12): 2651-2662.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 276.25 |
| Cas No. | 2070015-29-9 |
| Formula | C16H8N2O3 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥10.85 mg/mL in DMSO with gentle warming |
| Chemical Name | 2-(pyridin-3-yl)naphtho[2,3-d]oxazole-4,9-dione |
| SDF | Download SDF |
| Canonical SMILES | O=C(c1c2[o]c(-c3cnccc3)n1)c(cccc1)c1C2=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
