SJB3-019A
SJB3-019A is a potent and novel inhibitor of USP1 with IC50 value of 0.0781 μM [1].
Ubiquitin-specific protease 1 (USP1) is a deubiquitinating (DUB) enzyme and removes polyubiquitin chains from the DNA binding 1 (ID1) protein, which plays an important role in the proliferation and progression of cancers, such as leukemia [1].
SJB3-019A is a potent and novel USP1 inhibitor. In K562 cells, SJB3-019A exhibited 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity. In HeLa cells, SJB3-019A increased the levels of Ub-PCNA and Ub-FANCD2 and reduced the homologous recombination activity [1].
Reference:
[1]. Mistry H, Hsieh G, Buhrlage SJ, et al. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther, 2013, 12(12): 2651-2662.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 276.25 |
| Formula | C16H8N2O3 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥10.85 mg/mL in DMSO with gentle warming |
| Chemical Name | 2-(pyridin-3-yl)naphtho[2,3-d]oxazole-4,9-dione |
| SDF | Download SDF |
| Canonical SMILES | O=C(C1=C2OC(C3=CN=CC=C3)=N1)C4=CC=CC=C4C2=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
