TAK-243
Catalog No.
BA2722
TAK-243 (MLN7243) is a first-of-its-kind, selective ubiquitin-activating enzyme, inhibitor.
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TAK-243 (MLN7243) is a first-of-its-kind, selective ubiquitin-activating enzyme, inhibitor (=1nM), which blocks ubiquitin binding, disrupts monoubiquitin signaling and whole-protein ubiquitination.TAK-243 (MLN7243) induces endoplasmic reticulum stress (ERS) responses, eliminates pathway activation and promotes apoptosis.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 519.52 |
| Cas No. | 1450833-55-2 |
| Formula | C19H20F3N5O5S2 |
| Synonyms | MLN7243 |
| Solubility | ≥51.4 mg/mL in DMSO; ≥7.88 mg/mL in EtOH with ultrasonic; insoluble in H2O |
| Chemical Name | ((1R,2R,3S,4R)-2,3-dihydroxy-4-((2-(3-((trifluoromethyl)thio)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)cyclopentyl)methyl sulfamate |
| SDF | Download SDF |
| Canonical SMILES | O[C@@H]1[C@H](O)[C@@H](COS(N)(=O)=O)C[C@H]1NC2=CC=NC3=CC(C4=CC=CC(SC(F)(F)F)=C4)=NN32 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
