ML-323
Catalog No.
B1317
USP1-UAF1 inhibitor
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ML-323 (CAS 1572414-83-5) is a small molecule inhibitor selectively targeting the USP1-UAF1 deubiquitinase complex, with a reported IC50 of 76 nM. USP1-UAF1 participates in DNA damage response pathways by regulating ubiquitination status of proteins such as PCNA and FANCD2. In cellular assays, ML-323 inhibits USP1–UAF1-mediated deubiquitination, enhancing cisplatin-induced cytotoxicity in human NSCLC (H596) and osteosarcoma (U2OS) cells. The molecule shows minimal cytotoxicity alone and exhibits high selectivity over other human DUBs and protease families, providing a valuable research tool for DNA repair and cancer biology studies.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 384.48 |
| Cas No. | 1572414-83-5 |
| Formula | C23H24N6 |
| Solubility | ≥12.34 mg/mL in EtOH; ≥15.05 mg/mL in DMSO; ≥2.25 mg/mL in H2O |
| Chemical Name | (E)-1-(4-(1H-1,2,3-triazol-1-yl)phenyl)-N-(2-(2-isopropylphenyl)-5-methylpyrimidin-4(3H)-ylidene)methanamine |
| SDF | Download SDF |
| Canonical SMILES | CC(C1=CC=CC=C1C2=NC=C(/C(N2)=N\CC3=CC=C(N4C=CN=N4)C=C3)C)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | ML323 is a highly potent and selective inhibitor of USP1-UAF1 with IC50 value of 76 nM. | |||||
| Targets | USP1-UAF1 | |||||
| IC50 | 76 nM | |||||
Quality Control & MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
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