Sedanolide
Catalog No.
C5661
mosquitocidal, nematicidal, and antifungal
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Sedanolide (CAS number: 6415-59-4) is a naturally occurring phthalide isolated from plants such as celery seed oil. It exhibits antioxidant properties and has demonstrated inhibitory activity against cyclooxygenase-1 and -2 enzymes, as well as topoisomerase-I and -II. In hepatocellular carcinoma J5 cells, sedanolide induces autophagy through modulation of PI3K/Akt/mTOR signaling, elevating PI3K-III, LC3-II, and Beclin-1 expression, and activating p53 and NF-κB pathways. Although generally nontoxic, high concentrations were shown to cause DNA strand breaks in HepG2 cells. Sedanolide is used in research studying cancer cell autophagy and oxidative stress mechanisms.
| Storage | Store at -20°C |
| M.Wt | 194.3 |
| Cas No. | 6415-59-4 |
| Formula | C12H18O2 |
| Solubility | insoluble in H2O; ≥52.8 mg/mL in EtOH; ≥6.65 mg/mL in DMSO |
| Chemical Name | 3-butyl-3a,4,5,6-tetrahydro-1(3H)-isobenzofuranone |
| SDF | Download SDF |
| Canonical SMILES | O=C1OC(CCCC)C2CCCC=C21 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
