SBC-115076
Catalog No.
B5907
Anti-PCSK9 compound
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SBC-115076 (CAS 489415-96-5) is a small molecule targeting proprotein convertase subtilisin/kexin type 9 (PCSK9), a serine protease primarily expressed in liver and intestinal tissues. PCSK9 negatively regulates cellular low-density lipoprotein receptor (LDLR) levels through intracellular and extracellular binding, thereby influencing plasma cholesterol metabolism. SBC-115076 increases LDLR expression and dose-dependently enhances cellular uptake of dihydro-LDL in vitro. In high-fat diet-fed mouse models, SBC-115076 treatment significantly reduced total cholesterol levels, demonstrating potential utility in preclinical research as a therapeutic candidate for hypercholesterolemia and cardiovascular disease.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 527.61 |
| Cas No. | 489415-96-5 |
| Formula | C31H33N3O5 |
| Solubility | ≥52.8 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | 4-(4-(benzyloxy)-3-methylbenzoyl)-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC(C(C(C(N2CCCN3CCOCC3)C4=CC=NC=C4)=C(O)C2=O)=O)=CC=C1OCC5=CC=CC=C5 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
