L-Thyroxine
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 776.87 |
| Cas No. | 51-48-9 |
| Formula | C15H11I4NO4 |
| Solubility | ≥27.35 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid |
| SDF | Download SDF |
| Canonical SMILES | IC(C=C(C=C1I)C[C@@H](C(O)=O)N)=C1OC(C=C2I)=CC(I)=C2O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Animal experiment:[1] | |
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Animal models |
Weanling mice of the Swiss-Webster strain |
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Dosage form |
0.9 or 2.7 μg Administered subcutaneously 2 hours before the administration of purified porcine thyrotropin-releasing factor (TRF) |
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Applications |
L-Thyroxine inhibited synthesis and release of thyrotropin (TSH) induced by TRF from the anterior pituitary in mice. Complete inhibition of the TRF-TSH release response was achieved with 2.7 μg L-thyroxine and partial inhibition occurred with 0.9 μg L-thyroxine. The inhibition caused by L-thyroxine could be overcame by increasing the dose of TRF. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Bowers CY, Schally AV, Reynolds GA, et al. Interactions of L-thyroxine or L-triiodothyronine and thyrotropin-releasing factor on the release and synthesis of thyrotropin from the anterior pituitary gland of mice. Endocrinology, 1967, 81(4): 741-747. |
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Quality Control & MSDS
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Chemical structure
