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PA-824

Catalog No.
A1736
Anti-tuberculosis drug
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$61.00
In stock
5mg
$55.00
In stock
25mg
$110.00
In stock
100mg
$264.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

PA-824 (CAS 187235-37-6) is a bicyclic nitroimidazole derivative exhibiting antimycobacterial activity against Mycobacterium tuberculosis. Its bactericidal mechanism entails inhibition of ketomycolate biosynthesis and enzymatic nitro-reduction leading to intracellular release of nitric oxide, killing both replicating and non-replicating M. tuberculosis. Reported MIC values range from 0.015 μg/ml to 0.25 μg/ml. PA-824 demonstrates activity against drug-sensitive and drug-resistant tuberculosis strains, supporting its utility in tuberculosis research and therapeutic investigations.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt359.26
Cas No.187235-37-6
FormulaC14H12F3N3O5
Solubilityinsoluble in EtOH; insoluble in H2O; ≥17.85 mg/mL in DMSO
Chemical Name(6S)-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
SDFDownload SDF
Canonical SMILESC1C(COC2=NC(=CN21)[N+](=O)[O-])OCC3=CC=C(C=C3)OC(F)(F)F
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Biological Activity

Description PA-824 is an anti-tuberculosis drug with MIC value of < 2.8 μM.
Targets tuberculosis          
IC50 <2.8 μM          

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