PA-824
Catalog No.
A1736
Anti-tuberculosis drug
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PA-824 (CAS 187235-37-6) is a bicyclic nitroimidazole derivative exhibiting antimycobacterial activity against Mycobacterium tuberculosis. Its bactericidal mechanism entails inhibition of ketomycolate biosynthesis and enzymatic nitro-reduction leading to intracellular release of nitric oxide, killing both replicating and non-replicating M. tuberculosis. Reported MIC values range from 0.015 μg/ml to 0.25 μg/ml. PA-824 demonstrates activity against drug-sensitive and drug-resistant tuberculosis strains, supporting its utility in tuberculosis research and therapeutic investigations.
- 1. Nurlilah Ab Rahman, Samsher Singh, et al. "A bactericidal tuberculosis drug regimen driven by inhibition of the terminal oxidases by pretomanid." EMBO Mol Med. 2026 Mar;18(3):1009-1022. PMID: 41652042
- 2. Dirk A. Lamprecht, Richard J. Wall, et al. "Targeting de novo purine biosynthesis for tuberculosis treatment." Nature. 2025 Jun 18;644(8075):214–220. PMID: 40533558
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 359.26 |
| Cas No. | 187235-37-6 |
| Formula | C14H12F3N3O5 |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥17.85 mg/mL in DMSO |
| Chemical Name | (6S)-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine |
| Canonical SMILES | [O-][N+](c1c[n](C[C@@H](CO2)OCc(cc3)ccc3OC(F)(F)F)c2n1)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | PA-824 is an anti-tuberculosis drug with MIC value of < 2.8 μM. | |||||
| Targets | tuberculosis | |||||
| IC50 | <2.8 μM | |||||
Quality Control & MSDS
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Chemical structure
