DMPO
Catalog No.
B7401
Water soluble nitric oxide spin trap
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DMPO (CAS 3317-61-1) is a water-soluble spin trap employed extensively in free radical research. Through electron spin resonance (ESR) spectroscopy, it captures transient oxygen-centered radicals such as superoxide (·O??) and hydroxyl (·OH), enabling their identification and analysis in biological systems at physiological temperature. DMPO exhibits high reaction rate constants with these radicals, facilitating their detection and differentiation. Studies in red blood and hamster V79 cells indicate rapid metabolic decay of its spin adducts, complicating cellular radical detection. In vivo evidence from heart reperfusion models also shows DMPO's utility in attenuating radical-induced injury and associated arrhythmias.
- 1. Yichao Tao, Wenbin Zhuang, et al. "Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatment." iScience. 2025 Jan 27;28(2):111858 PMID: 40017508
- 2. Nan Wang, Pin Li, et al. "An anisotropic photocatalytic agent elicits robust photoimmunotherapy through plasmonic catalysis-mediated tumor microenvironment modulation." nanotoday. Volume 50, June 2023, 101827.
- 3. Jieyang Yang, Zequan Zeng, et al. "Acceleration of Persulfate Activation by MIL-101(Fe) with Vacuum Thermal Activation: Effect of FeII/FeIII Mixed-Valence Center." Catalysts 2019, 9(11), 906.
| Physical Appearance | A colorless oil |
| Storage | Store at -20°C |
| M.Wt | 113.16 |
| Cas No. | 3317-61-1 |
| Formula | C6H11NO |
| Solubility | ≥11.3 mg/mL in DMSO; ≥55.9 mg/mL in H2O; ≥65.8 mg/mL in EtOH |
| Chemical Name | 2,2-dimethyl-3,4-dihydro-2H-pyrrole 1-oxide |
| SDF | Download SDF |
| Canonical SMILES | [O-][N+]1=CCCC1(C)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
Related Biological Data
