Kif15-IN-1
Catalog No.
B3280
potent Kif15 kinesin inhibitor
Featured Products
Kif15-IN-1 (CAS 672926-32-8) is a small molecule inhibitor targeting kinesin family member 15 (Kif15), also termed kinesin-12 or HKLP2. Kif15 is a kinesin-related motor protein expressed during mitosis, crucially involved in the formation and stabilization of bipolar microtubule spindles, acting redundantly with KIF11 (Eg5). Inhibition of Kif15 by Kif15-IN-1 results in suppression of tumor cell proliferation, highlighting its utility in cell biology research focused on mitotic spindle mechanics and its potential in oncology as a candidate for antiproliferative strategies.
- 1. Geng-Yuan Chen, Fioranna Renda, et al. "Tension promotes kinetochore–microtubule release by Aurora B kinase." J Cell Biol. 2021 Jun 7;220(6):e202007030. PMID:33904910
- 2. Lee J, Cho YJ, et al. "KSP siRNA/paclitaxel-loaded PEGylated cationic liposomes for overcoming resistance to KSP inhibitors: Synergistic antitumor effects in drug-resistant ovarian cancer." J Control Release. 2020 Feb 6;321:184-197. PMID:32035195
- 3. Milic B, Chakraborty A, et al. "KIF15 nanomechanics and kinesin inhibitors, with implications for cancer chemotherapeutics." Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4613-E4622. PMID:29703754
| Storage | Store at -20°C |
| M.Wt | 430.48 |
| Cas No. | 672926-32-8 |
| Formula | C20H22N4O5S |
| Solubility | insoluble in H2O; insoluble in DMSO; ≥19.2 mg/mL in EtOH |
| Chemical Name | (S,Z)-N-(5-(ethoxycarbonyl)-4-methylthiazol-2-yl)-2-(2-hydroxy-4-oxoquinazolin-3(4H)-yl)-3-methylbutanimidic acid |
| SDF | Download SDF |
| Canonical SMILES | CCOC(C(S1)=C(N=C1/N=C(O)/[C@](N2C(C3=CC=CC=C3N=C2O)=O)([H])C(C)C)C)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
Related Biological Data
Related Biological Data
Related Biological Data
Related Biological Data
