BIBP 3226 trifluoroacetate
Catalog No.
B7155
Mixed NPY Y1 and NPFF receptor antagonist
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BIBP 3226 trifluoroacetate (CAS: 1068148-47-9) is a non-peptide antagonist targeting neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptors, showing binding affinity with Ki values of 1.1 nM (rNPY Y1), 79 nM (hNPFF2), and 108 nM (rNPFF). BIBP 3226 competes with NPFF, prevents NPFF-induced inhibition of forskolin-stimulated cAMP production, and blocks NPFF-dependent hypothermic and anti-opioid effects in rodent models. This compound is employed experimentally to investigate NPY/NPFF system roles in anxiety, analgesia, and cardiovascular regulation.
| Physical Appearance | Off-white solid |
| Storage | Store at -20°C |
| M.Wt | 587.59 |
| Cas No. | 1068148-47-9 |
| Formula | C29H32F3N5O5 |
| Solubility | ≥78 mg/mL in DMSO; ≥73.2 mg/mL in EtOH; ≥12.13 mg/mL in H2O with ultrasonic |
| Chemical Name | rac-(R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hydroxybenzyl)pentanamide 2,2,2-trifluoroacetate |
| SDF | Download SDF |
| Canonical SMILES | FC(F)(C(O)=O)F.OC1=CC=C(C=C1)CNC([C@@H](CCCNC(N)=N)NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
