Vitamin D3
Catalog No.
B2065
A fat-soluble steroid; combined with nicotine (VDN method) it induces vascular calcification rat models.
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Vitamin D3 (Cholecalciferol, CAS 67-97-0) is a fat-soluble steroid and the naturally occurring form of vitamin D. After metabolic activation by hydroxylation, it primarily binds the nuclear vitamin D receptor (VDR) and regulates gene expression pathways related to cell differentiation and proliferation, inducing cell differentiation and inhibiting the proliferation of various cancer cells. Combined with nicotine (the VDN method), it induces a rat vascular calcification model.
- 1. Yongdeok Jo, Priya Kushram, et al. "Curcumin and vitamin D3 release from calcium phosphate enhances bone regeneration." Biomater Sci . 2025 Mar11;13(6):1568-1577 PMID: 39960074
- 2. Naboneeta Sarkar, Yongdeok Jo, Priya Kushram. "Multiple Drug Delivery Ability of Calcium Phosphate Scaffolds promotes Osteogenic Gene Expression in In Vitro Co-culture Model." Original Research 02 September 2025
- 3. Yongdeok Jo, Ujjayan Majumdar, et al. "Vitamin D3 Release from MgO Doped 3D Printed TCP Scaffolds for Bone Regeneration." ACS Biomater Sci Eng. 2024 Mar 11;10(3):1676-1685 PMID: 38386843
- 4. Kang Rong, Qingmin He, et al. "The mechanism of vitamin D3 in preventing colorectal cancer through network pharmacology." Front Pharmacol. 2023 May 17:14:1192210 PMID: 37266156
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 384.64 |
| Cas No. | 67-97-0 |
| Formula | C27H44O |
| Solubility | insoluble in H2O; ≥51.6 mg/mL in DMSO; ≥77.2 mg/mL in EtOH |
| Chemical Name | (S,Z)-3-(2-((1R,3aS,7aR,E)-7a-methyl-1-((R)-6-methylheptan-2-yl)octahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexan-1-ol |
| Canonical SMILES | C[C@@]12[C@](\C(=C\C=C\3/C(=C)CC[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](CCCC(C)C)C)[H])[H] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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