Trimethoprim
Catalog No.
B2057
bacteriostatic antibiotic
Featured Products
Trimethoprim (CAS: 738-70-5) is a small-molecule inhibitor targeting bacterial dihydrofolate reductase (DHFR), thereby disrupting folate metabolism and nucleic acid synthesis in bacteria. Trimethoprim demonstrates inhibitory activity with IC50 values ranging from approximately 5 to 15 nM against bacterial DHFR enzymes. BTrimethoprim holds research potential in studies of microbiology, urinary tract infections, bacterial metabolism, folate biosynthesis, antimicrobial resistance, and in the pharmacological profiling of antibacterial agents.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 290.32 |
| Cas No. | 738-70-5 |
| Formula | C14H18N4O3 |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥28.93 mg/mL in DMSO |
| Chemical Name | 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine |
| SDF | Download SDF |
| Canonical SMILES | COc1cc(Cc2c(N)nc(N)nc2)cc(OC)c1OC |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
Chemical structure
Related Biological Data
