S0859
Catalog No.
A3783
NBC inhibitor,potent and selective
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S0859, an N-cyanosulphonamide compound, reversibly inhibited NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). Na(+)-coupled HCO(3)(-) transporters (NBCs) mediate the transport of bicarbonate ions across cell membranes and are thus ubiquitous regulators of intracellular pH. NBC dysregulation is associated with a range of diseases; for instance, NBCn1 is strongly up-regulated in a model of ErbB2-dependent breast cancer, a malignant and widespread cancer with no targeted treatment options, and single-nucleotide polymorphisms in NBCn1 genetically link to breast cancer development and hypertension. Treatment with NBC inhibitor S0859 significantly increased caspase-3 activity and elevated the number of apoptotic EC. S0859 is potentially important for probing the transporter's functional role in heart and other tissues.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 530.04 |
| Cas No. | 1019331-10-2 |
| Formula | C29H24ClN3O3S |
| Synonyms | S 0859;S-0859 |
| Solubility | ≥45 mg/mL in DMSO; ≥45 mg/mL in EtOH; ≥24.5 mg/mL in H2O |
| Chemical Name | 2-chloro-N-((2'-(N-cyanosulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(4-methylbenzyl)benzamide |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC=C(CN(C(C2=CC=CC=C2Cl)=O)CC3=CC=C(C4=CC=CC=C4S(=O)(NC#N)=O)C=C3)C=C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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