Pyrvinium Pamoate
Catalog No.
B8393
A compound for the treatment of intestinal helminth infection that inhibits the Wnt signaling pathway
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Payrvinium pamoate is an ancient anthelmintic used to treat intestinal helminthiasis. As it inhibits the Wnt / β-catenin pathway in certain types of cancer, it has attracted attention as an anticancer drug. In vitro, palmitate pyruvate treatment inhibited AKT-mediated phosphorylation of GSK3β at S9 and reduced the protein levels of β-catenin and its downstream targets (c-Myc, cyclin D1). In addition, palmitate pyruvate significantly inhibited migration and invasion in vitro.
| Storage | Store at -20°C |
| M.Wt | 1151.39 |
| Cas No. | 3546-41-6 |
| Formula | C75H70N6O6 |
| Synonyms | Pyrvinium embonate |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥8.6 mg/mL in DMSO |
| Chemical Name | (E)-2-(2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)vinyl)-6-(dimethylamino)-1-methylquinolin-1-ium 4,4'-methylenebis(3-hydroxy-2-naphthoate) |
| Canonical SMILES | OC1=C(C([O-])=O)C=C2C=CC=CC2=C1CC3=C4C=CC=CC4=CC(C([O-])=O)=C3O.C[N+]5=C6C(C=C(N(C)C)C=C6)=CC=C5/C=C/C7=C(C)N(C8=CC=CC=C8)C(C)=C7.C[N+]9=C%10C(C=C(N(C)C)C=C%10)=CC=C9/C=C/C%11=C(C)N(C%12=CC=CC=C%12)C(C)=C%11 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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