Nirmatrelvir (PF-07321332)
Catalog No.
B8579
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Nirmatrelvir (PF-07321332; CAS 2628280-40-8) is an orally bioavailable inhibitor targeting the SARS-CoV-2 3-chymotrypsin-like protease (3CL^PRO). The viral 3CL^PRO enzyme facilitates cleavage of coronavirus polyproteins 1a and 1ab, a crucial step required for release of functional nonstructural proteins essential for viral replication. By selectively inhibiting 3CL^PRO activity, nirmatrelvir prevents polyprotein processing, thereby disrupting viral replication. Given its oral administration profile, nirmatrelvir provides significant research value for investigating antiviral therapeutics in outpatient settings and researching SARS-CoV-2 infection dynamics.
| Storage | Store at -20°C |
| M.Wt | 499.54 |
| Cas No. | 2628280-40-8 |
| Formula | C23H32F3N5O4 |
| Solubility | ≥23 mg/mL in DMSO; ≥9.8 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | (1R,2S,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | O=C1NCC[C@H]1C[C@H](NC([C@H]2N(C[C@H]3[C@@H]2C3(C)C)C([C@@H](NC(C(F)(F)F)=O)C(C)(C)C)=O)=O)C#N |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
