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Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell

Catalog No.
A1112
Blocker of NO production
Grouped product items
SizePriceStock Qty
1mg
$60.00
In stock
5mg
$180.00
In stock
10mg
$300.00
In stock
25mg
$420.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. NOS is known to exist in three isoforms: (a) a soluble constitutively expressed enzyme found in high concentrations in the brain (bNOS, nNOS, or NOS-1), (b) a constitutively expressed endothelial membrane bound enzyme (eNOS or NOS-3), and (c) an inducible enzyme (iNOS or NOS-2) that is associated with the cytotoxic function of macrophages. [1]

Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell (Ac-Pro-Tyr-Asn-Ser-Ser-Pro-Arg-Pro-Glu-Gln-His-Lys-Ser-Tyr-Lys-Cys) is a peptide that inhibit the function of NOSs as a result it blocks the production of NO. Because of the involvement of all the three NOS isozymes in various aspects of signal transduction, NOS inhibitors have gained prominence in the management of ischemic reperfusion injury, hypotensive effects of drugs, and inflammatory response to cytokines. [2][3]

Ref:

1. Achike, F.I., and Kwan, C.Y. 2003. Clin. Exp. Pharmacol. Physiol. 30, 605.

2. Chu, C.J., et al. 2000. Clin. Sci. 99, 475.


3.Mori. M., and Gotoh, T. 2000. Biochem. Biophys. Res. Commun. 275, 715.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1963.13
FormulaC85H127N25O27S
SynonymsAc-Pro-Tyr-Asn-Ser-Ser-Pro-Arg-Pro-Glu-Gln-His-Lys-Ser-Tyr-Lys-Cys-OH
Solubility≥196.3 mg/mL in DMSO; ≥53.8 mg/mL in EtOH; ≥60.1 mg/mL in H2O
SDFDownload SDF
Canonical SMILESO=C(NC(CC1=CC=C(O)C=C1)C(NC(CC(N)=O)C(NC(CO)C(NC(CO)C(N2CCCC2C(NC(CCCNC(N)=N)C(N3CCCC3C(NC(CCC(O)=O)C(NC(CCC(N)=O)C(NC(CC4=CN=CN4)C(NC(CCCCN)C(NC(CO)C(NC(CC5=CC=C(O)C=C5)C(NC(CCCCN)C(NC(CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C6CCCN6C(C)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

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Chemical structure

Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell