Neurotensin
Catalog No.
B5226
NTR1 activator
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Neurotensin (CAS 39379-15-2) is a 13-amino acid neuropeptide acting primarily through neurotensin receptor 1 (NTR1), a G protein-coupled receptor prominently expressed in the central nervous system and intestinal tissues. Binding of neurotensin to NTR1 initiates intracellular signaling cascades, including modulation of miRNA expression. For instance, neurotensin-induced upregulation of miR-133α in human colonic epithelial cells affects receptor recycling by targeting aftiphilin (AFTPH), a protein linked to receptor trafficking via endosomal and trans-Golgi network pathways. Neurotensin thus serves as an important tool for understanding GPCR trafficking mechanisms and miRNA regulation in gastrointestinal physiology and pathology.
- 1. Pengjie Zhang, Bin Du, et al. "Identification and Removal of Pollen Spectral Interference in the Classification of Hazardous Substances Based on Excitation Emission Matrix Fluorescence Spectroscopy" Molecules. 2024 Jul 1;29(13):3132 PMID: 38999084
- 2. Jiwei Xu, Jianjie Xu, et al. "Impact of different classification schemes on discrimination of proteins with noise-contaminated spectra using laboratory-measured fluorescence data." Spectrochim Acta A Mol Biomol Spectrosc. 2023 Aug 5:296:122646. PMID: 37003145
| Physical Appearance | White lyophilised solid |
| Storage | Desiccate at -20°C |
| M.Wt | 1672.94 |
| Cas No. | 39379-15-2 |
| Formula | C78H121N21O20 |
| Solubility | insoluble in EtOH; ≥15.33 mg/mL in DMSO; ≥22.55 mg/mL in H2O |
| Chemical Name | (Z)-5-(((Z)-1-((6-amino-1-(2-((Z)-(((Z)-1-((1-(2-((Z)-(((Z)-1-(((Z)-1-((1-carboxy-3-methylbutyl)imino)-1-hydroxy-3-methylpentan-2-yl)imino)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl)imino)(hydroxy)methyl)pyrrolidin-1-yl)-5-guanidino-1-oxopentan-2-yl)imino) |
| SDF | Download SDF |
| Canonical SMILES | CCC(C(/N=C(O)/C(/N=C(O)/C1CCCN1C(C(/N=C(O)/C(/N=C(O)/C2CCCN2C(C(/N=C(O)/C(/N=C(O)/C(/N=C(O)/C(/N=C(O)/C(/N=C(O)/C3CCC(O)=N3)CC(C)C)CC4=CC=C(O)C=C4)CCC(O)=O)CC(O)=N)CCCCN)=O)CCCNC(N)=N)CCCNC(N)=N)=O)CC5=CC=C(O)C=C5)/C(O)=N/C(C(O)=O)CC(C)C)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
