Neomycin sulfate
Neomycin sulfate (CAS 1405-10-3) is an aminoglycoside antibiotic that interacts with nucleic acid structures and ion channels, influencing several biological processes. It inhibits hammerhead ribozyme cleavage reactions by preferentially stabilizing the ribozyme-substrate ground-state complex, thereby impeding catalytic turnover. In HIV-1 research, neomycin disrupts the interaction between Tat protein and the viral RNA TAR element via an allosteric, noncompetitive mechanism. Additionally, neomycin binds specifically to DNA triplex structures, particularly stabilizing TAT triplets. It also demonstrates voltage- and concentration-dependent blockage of ryanodine receptor channels, mainly from the luminal side. These properties make neomycin sulfate valuable for mechanistic studies involving RNA/DNA structure interactions and channel functions.
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| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 712.72 |
| Cas No. | 1405-10-3 |
| Formula | C23H46N6O13·H2SO4 |
| Solubility | ≥33.75 mg/mL in H2O; insoluble in DMSO; insoluble in EtOH |
| Chemical Name | (2R,3R,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4R,5R)-4-[(3R,4R,5R,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid |
| SDF | Download SDF |
| Canonical SMILES | C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
