Vancomycin
Vancomycin (CAS 1404-90-6) is an antibacterial agent obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to the kidney and inner ear. High-dose administration induces acute kidney injury (nephrotoxicity) models in rats/mice.
Vancomycin inhibits bacterial cell wall synthesis by binding to the D-Ala-D-Ala terminus of peptidoglycan precursors, thereby preventing normal polymerization and cross-linking. Vancomycin is also an important tool for studying bacterial resistance mechanisms.
As of January 29, 2018, CutisPharma's Firvanq was the only FDA-approved oral liquid vancomycin treatment option for Clostridioides difficile-associated diarrhea and enteritis caused by Staphylococcus aureus (including methicillin-resistant strains) [LP1196]. Compared with previously available dedicated compounded formulations, this oral liquid dosage form provides a new option for the treatment of Clostridioides difficile-associated diarrhea [LP1196].
- 1. Shuiping Yan, Jian Zheng, et al. "Effect of Shufeng Xingbi Therapy on Th1/Th2 immune balance and intestinal flora in rats with allergic rhinitis." bioRxiv. March 29, 2025
- 2. Fuqiang Ma, Weiming Zhang, et al. "Epimedii Folium decoction ameliorates osteoporosis in mice through NLRP3/caspase-1/IL-1β signalling pathway and gut-bone axis." Int Immunopharmacol. 2024 Aug 20:137:112472. PMID: 38897131
- 3. Song Deng, Chaoying Pei, et al. "Lactobacillus acidophilus and its metabolite ursodeoxycholic acid ameliorate ulcerative colitis by promoting Treg differentiation and inhibiting M1 macrophage polarization." Front Microbiol. 2024 Jan 16:15:1302998. PMID: 38292253
| Storage | Store at -20°C |
| M.Wt | 1449.25 |
| Cas No. | 1404-90-6 |
| Formula | C66H75Cl2N9O24 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥97.2 mg/mL in DMSO |
| Canonical SMILES | CN[C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)C2=CC=C(OC3=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@H]4C[C@](C)(N)[C@H](O)[C@H](C)O4)C4=CC(=C3)[C@@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N[C@@H]1C3=CC(=C(O)C=C3)C3=C(O)C=C(O)C=C3[C@H](NC(=O)[C@@H](NC1=O)[C@H](O)C1=CC(Cl)=C(O4)C=C1)C(O)=O)C(Cl)=C2 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
