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Myriocin

Catalog No.
B6064
immunosuppressant and specific serine palmitoyltransferase inhibitor
Grouped product items
SizePriceStock Qty
5mg
$102.00
Ship with 5-10 days
10mg
$167.00
Ship with 5-10 days
25mg
$293.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

Myriocin (CAS 35891-70-4) is a selective inhibitor of serine palmitoyltransferase (SPT), an enzyme catalyzing the initial step in de novo sphingolipid biosynthesis. By inhibiting this pathway (Ki = 0.28 nM), myriocin exerts immunosuppressive and antiproliferative effects. In vitro studies show dose-dependent inhibition of cell growth in A549 (IC50 = 30 μM) and NCI-H460 (IC50 = 26 μM) lung cancer cell lines. In vivo, myriocin suppresses tumor formation in murine melanoma models and influences expression of cell cycle regulators (Cdc25C, Cdc2, cyclin B1) and tumor suppressor pathways (p53, p21). Myriocin is thus utilized in research exploring sphingolipid metabolism, oncology, and immunology.

Product Citation

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt401.54
Cas No.35891-70-4
FormulaC21H39NO6
Solubility2mg/mL in methanol
Chemical Name(2S,3R,4R,E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid
SDFDownload SDF
Canonical SMILESCCCCCCC(CCCCCC/C([H])=C([H])/C[C@](O)([H])[C@@](O)([H])[C@@](C(O)=O)(N)CO)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

Myriocin

Related Biological Data

Myriocin

Related Biological Data

Myriocin

Related Biological Data

Myriocin