Myriocin
Myriocin (CAS 35891-70-4) is a selective inhibitor of serine palmitoyltransferase (SPT), an enzyme catalyzing the initial step in de novo sphingolipid biosynthesis. By inhibiting this pathway (Ki = 0.28 nM), myriocin exerts immunosuppressive and antiproliferative effects. In vitro studies show dose-dependent inhibition of cell growth in A549 (IC50 = 30 μM) and NCI-H460 (IC50 = 26 μM) lung cancer cell lines. In vivo, myriocin suppresses tumor formation in murine melanoma models and influences expression of cell cycle regulators (Cdc25C, Cdc2, cyclin B1) and tumor suppressor pathways (p53, p21). Myriocin is thus utilized in research exploring sphingolipid metabolism, oncology, and immunology.
- 1. Libo He, Jinye Dang, et al. "Myriocin Restores Metabolic Homeostasis in dAGE-Exposed Mice via AMPK-PGC1α-Mediated Mitochondrial Activation and Systemic Lipid/Glucose Regulation." Nutrients. 2025 Apr 30;17(9):1549 PMID: 40362857
- 2. Xu Hong, Sheng Wang, et al. "Bisphenol A Exacerbates Colorectal Cancer Progression through Enhancing Ceramide Synthesis." Toxicology. 2025 Jan12:511:154054 PMID: 39809339
- 3. Ting Wang, Jingmin Zhang, et al. "Lipidomics Analysis Reveals Protective Effect of Myriocin on Cerebral Ischemia/Reperfusion Model Rats." Research Square. rs-1324750/v1.
- 4. Xue-Ming Zhu, Lin Li, et al. "A VASt-domain protein regulates autophagy, membrane tension, and sterol homeostasis in rice blast fungus." Autophagy. 2020 Nov 11. PMID:33176558
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 401.54 |
Cas No. | 35891-70-4 |
Formula | C21H39NO6 |
Solubility | 2mg/mL in methanol |
Chemical Name | (2S,3R,4R,E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid |
SDF | Download SDF |
Canonical SMILES | CCCCCCC(CCCCCC/C([H])=C([H])/C[C@](O)([H])[C@@](O)([H])[C@@](C(O)=O)(N)CO)=O |
Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure

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