JC-1
Catalog No.
A3516
Probe for Mitochondrial Membrane Potential
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JC-1 (CAS: 3520-43-2) is a fluorescent probe commonly utilized to evaluate mitochondrial membrane potential, thereby serving as a functional indicator of mitochondrial activity. Within cells, JC-1 selectively accumulates in mitochondria in a membrane-potential-dependent manner, shifting fluorescence emission from green to red as it forms aggregates at higher mitochondrial potentials. This fluorescence shift allows researchers to monitor mitochondrial membrane integrity and assess cellular metabolic states. JC-1 is widely applied in studies of apoptosis, mitochondrial dysfunction, and cellular bioenergetics.
- 1. Jingjing Liu, Qingcan Guan, et al. "Melatonin Alleviates MBP-Induced Oxidative Stress and Apoptosis in TM3 Cells via the SIRT1/PGC-1α Signaling Pathway." Int J Mol Sci. 2025 Jun 19;26(12):5910 PMID: 40565373
- 2. Xiao‑Xin Yang, Xiang Xu, et al. "A nanoreactor boosts chemodynamic therapy and ferroptosis for synergistic cancer therapy using molecular amplifier dihydroartemisinin." J Nanobiotechnology. 2022 May 14;20(1):230. PMID: 35568865
- 3. Liyuan Zou, Xiaokun Ma, et al. "Protective Effect of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes on Cardiomyoblast Hypoxia-Reperfusion Injury Through the miR-149/let-7c/Faslg Axis." Free Radic Res. 2020 Oct;54(10):722-731. PMID: 33054503
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 652.23 |
| Cas No. | 3520-43-2 |
| Formula | C25H27Cl4IN4 |
| Synonyms | CBIC2;JC1;JC 1 |
| Solubility | ≥32.6 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O |
| Chemical Name | 5,6-dichloro-2-[(E)-3-(5,6-dichloro-1,3-diethylbenzimidazol-3-ium-2-yl)prop-2-enylidene]-1,3-diethylbenzimidazole;iodide |
| SDF | Download SDF |
| Canonical SMILES | CCN1C2=CC(=C(C=C2[N+](=C1C=CC=C3N(C4=CC(=C(C=C4N3CC)Cl)Cl)CC)CC)Cl)Cl.[I-] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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