Foxy-5 TFA
Foxy-5 (TFA), a Wnt5a peptide mimetic with clear anti-cancer activity, can significantly enhance the adhesion ability of MDA-MB-468 breast cancer cells and effectively inhibit their migratory activity when used at concentrations ranging from 1 to 1000 μM. In a mouse xenograft model established with DU145-Luc cells, administration of this compound at a dose of 2 mg/kg significantly reduced the number of lymph node metastases; however, it did not show a significant effect on the growth of the primary tumor.
References：
[1] Säfholm A, Leandersson K, Dejmek J, Nielsen CK, Villoutreix BO, Andersson T. A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells. J Biol Chem. 2006 Feb 3;281(5):2740-9. doi: 10.1074/jbc.M508386200. Epub 2005 Dec 5. PMID: 16330545.
[2] Canesin G, Evans-Axelsson S, Hellsten R, Krzyzanowska A, Prasad CP, Bjartell A, Andersson T. Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One. 2017 Sep 8;12(9):e0184418. doi: 10.1371/journal.pone.0184418. PMID: 28886116; PMCID: PMC5590932.
| Storage | Store at -20°C |
| M.Wt | 808.80 |
| Cas No. | 881188-51-8 |
| Formula | C28H43F3N6O14S2 |
| Synonyms | N-formyl-Met-Asp-Gly-Cys-Glu-Leu;N-formyl-MDGCEL |
| Chemical Name | (2S,5S,8R,14S)-5-(2-carboxyethyl)-14-((S)-2-formamido-4-(methylthio)butanamido)-2-isobutyl-8-(mercaptomethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazahexadecanedioic acid--2,2,2-trifluoroacetic acid (1/1) |
| SDF | Download SDF |
| Canonical SMILES | OC(CC[C@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC=O)CCSC)=O)CC(O)=O)=O)=O)CS)=O)C(N[C@H](C(O)=O)CC(C)C)=O)=O.FC(F)(F)C(O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
