Folic acid
Catalog No.
N2075
A nutrient that reduces neonatal neural tube defect risk; high-dose (~250 mg/kg) intraperitoneal injection induces acute tubular necrosis and folate nephropathy (AKI) in rats and mice, a common model for evaluating renoprotective drugs.
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Folic acid (vitamin B9, CAS 59-30-3) is a water-soluble B9 vitamin structurally derived from spinach. It acts as a cofactor in one-carbon transfer reactions, promoting nucleotide synthesis and methylation processes that are essential for DNA replication and cell division. Folic acid is commonly used in research on cell proliferation, gene expression regulation, and metabolic disorders.
Intraperitoneal injection of a high dose (approximately 250 mg/kg) of folic acid induces acute tubular necrosis and folic acid nephropathy (AKI) in rats/mice, and is a commonly used model for renal injury and renoprotective drug evaluation.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 441.4 |
| Cas No. | 59-30-3 |
| Formula | C19H19N7O6 |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥18 mg/mL in DMSO with gentle warming |
| Chemical Name | (4-(((2-amino-4-oxo-4,8-dihydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid |
| Canonical SMILES | O=C1C=2C(NC=C(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)N2)=NC(N)=N1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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