Elbasvir
Catalog No.
A9068
Hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitor.
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Elbasvir (alias: MK-8742) is a potent direct-acting antiviral that inhibits hepatitis C virus (HCV) nonstructural protein 5A (NS5A), with an EC50 of 2.2 pM in Huh7 human hepatocellular carcinoma cells expressing the pH77S.3/GLuc2A construct. pH77S.3/GLuc2A is a cell culture-adapted HCV genotype 1a derivative and contains a luciferase reporter gene. After 48 hours of in vitro exposure, Elbasvir effectively blocks NS5A, a protein critical for HCV RNA synthesis and virion assembly, and at 50 pM inhibits the formation of new viral replicase complexes. Formulations containing Elbasvir have been used alone or in combination with NS3/4A protease inhibitors for the treatment of HCV.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 882.04 |
| Cas No. | 1370468-36-2 |
| Formula | C49H55N9O7 |
| Synonyms | MK-8742 |
| Solubility | ≥46.4 mg/mL in DMSO; ≥39.3 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | dimethyl ((2S,2'S)-((2S,2'S)-(((S)-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-1,2-diyl))dicarbamate |
| Canonical SMILES | O=C([C@H](C(C)C)NC(OC)=O)N(CCC1)[C@@H]1C(N2)=NC=C2C3=CC=C(N([C@H](C4=CC=CC=C4)OC5=C6C=CC(C7=CN=C([C@H]8N(C([C@H](C(C)C)NC(OC)=O)=O)CCC8)N7)=C5)C6=C9)C9=C3 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |