DOTMA
DOTMA is a tetramethylated DOTA analog. As a cationic lipid, it is used as a component of liposomes and serves as a non-viral vector for gene therapy. DOTMA induces a positive charge on liposomes, thereby promoting effective interactions between liposomes and the cell membrane. It is commonly used for the delivery of siRNA, microRNA, and oligonucleotides, as well as for in vitro gene transfection, and shows very good gene transfection performance both in vitro and in vivo.
DOTMA, a tetramethylated DOTA analogue, is a cationic lipid used as a component of liposomes. DOTMA induces a positive charge on the liposomes, thus promoting effective interaction between the liposomes and the cell membrane. It is often used for delivery of siRNA, microRNA and oligonucleotides, as well as in vitro gene transfection, showing good transfection effect in vitro and in vivo.
| Storage | Store at -20°C |
| M.Wt | 670.59 |
| Cas No. | 104872-42-6 |
| Formula | C42H84ClNO2 |
| Solubility | ≥10.6 mg/mL in DMSO with ultrasonic; ≥52.9 mg/mL in EtOH; ≥2.58 mg/mL in H2O with gentle warming and ultrasonic |
| Chemical Name | N,N,N-trimethyl-3-(((E)-octadec-7-en-1-yl)oxy)-2-(((E)-octadec-9-en-1-yl)oxy)propan-1-aminium chloride |
| SDF | Download SDF |
| Canonical SMILES | CCCCCCCC/C=C/CCCCCCCCOC(C[N+](C)(C)C)COCCCCCC/C=C/CCCCCCCCCC.[Cl-] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
