1,2-Dioleoyl-sn-glycero-3-PE
Catalog No.
C4956
Neutral helper lipid for enhancing liposomal transfection efficiency and lipid membrane fusion
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1,2-Dioleoyl-sn-glycero-3-PE (DOPE) is a core helper phospholipid for cationic liposomes. After cellular internalization, it triggers membrane fusion in the acidic endosomal microenvironment, facilitating the release of encapsulated nucleic acids from endosomes into the cytoplasm and thereby boosting transfection efficiency. It is commonly formulated with cationic lipids and DSPE-PEG, and widely applied in the development of LNP-based nucleic acid delivery systems, in vitro transfection reagents, genetic vaccine carriers, as well as anti-tumor nanomedicines.
- 1. Yuming Ma, Qiao Liu, et al. "Fungus Derived Indole‐3‐Acetic Acid Controls Developmental Conidial Death in Magnaporthe oryzae." Mol Plant Pathol. 2026 Apr;27(4):e70252. PMID: 41905895
- 2. Haizong Fang, Peidong You, et al. "Annexin A1 mRNA-loaded liposomes alleviate acute pancreatitis by suppressing STING pathway and promoting efferocytosis in macrophages." Nat. Nanotechnol. (2025)
- 3. Qiao Liu, Ruhui Long, et al. "Phosphatidylethanolamines link ferroptosis and autophagy during appressorium formation of rice blast fungus." Mol Plant Pathol. 2024 Jul;25(7):e13489. PMID: 38956897
- 4. Qiao Liu, Ruhui Long, et al. "PUFA-PLs biosynthesis enzymes contribute to pathogenic development of rice blast fungus Magnaporthe oryzae." Mycology An International Journal on Fungal Biology Volume 15, 2024. PMID: 39678643
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 744.03 |
| Cas No. | 4004-05-1 |
| Formula | C41H78NO8P |
| Synonyms | DOPE |
| Solubility | ≥2.28 mg/mL in DMSO with gentle warming and ultrasonic; ≥4.25 mg/mL in EtOH with ultrasonic; insoluble in H2O |
| Chemical Name | 2-ammonioethyl ((R)-2,3-bis(oleoyloxy)propyl) phosphate |
| Canonical SMILES | CCCCCCCC/C=C\CCCCCCCC(O[C@H](COC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OCC[NH3+])([O-])=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
