DiR
DiR, also called DiIC18(7), is a deep-red fluorescent probe that is widely used as a lipophilic tracker in living and fixed tissues and cells. DiR can insert into the membrane, and diffuse rapidly, staining the entire membrane surface red. DiR usually does not affect cell viability and development, so it is commonly used in cell tracking, such as anterograde and retrograde neuronal tracking. DiR has remained viable for up to four weeks in culture and up to one year in vivo.
DiR is useful for in vivo imaging due to the effective transmission of infrared light through cells and tissues and low autofluorescence in the infrared range. In addition, DiR has many other applications including detecting cell-cell fusion and adhesion, tracking cell migration, and labeling lipoproteins.
- 1. Hongman Liu, Mengting Li, et al. "An integrated “Engage & Evasion” approach for mononuclear phagocyte system escape and efficient extracellular vesicle therapy." J Nanobiotechnol 22, 770 (2024).
- 2. Linfu Chen, Zheyu Kang, et al. "An emerging antibacterial nanovaccine for enhanced chemotherapy by selectively eliminating tumor-colonizing bacteria." Sci Bull (Beijing). 2024 Jun 14:S2095-9273(24)00427-4. PMID: 38918142
| Storage | Store at -20°C, away from light |
| M.Wt | 1013.42 |
| Cas No. | 100068-60-8 |
| Formula | C63H101IN2 |
| Synonyms | Cy7 DiC18 |
| Solubility | ≥19.8 mg/mL in DMSO; ≥29.35 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | 2-((1E,3E,5E)-7-((E)-3,3-dimethyl-1-octadecylindolin-2-ylidene)hepta-1,3,5-trien-1-yl)-3,3-dimethyl-1-octadecyl-3H-indol-1-ium iodide |
| SDF | Download SDF |
| Canonical SMILES | CCCCCCCCCCCCCCCCCC[N+]1=C(/C=C/C=C/C=C/C=C2C(C)(C)C(C=CC=C3)=C3N\2CCCCCCCCCCCCCCCCCC)C(C)(C)C4=C1C=CC=C4.[I-] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
Chemical structure
| Components | B8806-5 mg | B8806-10 mg |
| DiR | 5 mg | 10 mg |
The product should be stored at -20°C away from light and moisture. Stable for 1 year. The stock solution should be stored at -20°C away from light. Stable for 6 months. | ||