Chlorpromazine
Catalog No.
C6410
A dopamine receptor antagonist, classified as a typical antipsychotic drug
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Chlorpromazine (CAS 50-53-3) is a phenothiazine-class antipsychotic agent widely studied and utilized in biomedical research. It acts primarily by antagonizing postsynaptic dopamine D2 receptors within the mesolimbic neuronal pathway, providing therapeutic effects for schizophrenia, bipolar disorder, and psychotic episodes. Additionally, chlorpromazine exerts antiemetic properties through simultaneous blockade of dopamine D2, histamine H1, and muscarinic M1 receptors within central vomiting centers, thus supporting its experimental use in nausea and vomiting models. It is typically available as hydrochloride salt formulations for oral and injectable administration or in base form as suppositories.
- 1. Guanlin Zhou, Chao Wang, et al. "Alternating magnetic field pretreatment promotes cellular endocytosis to enhance the efficacy of magnetic hyperthermia." Volume 114, Part A, December 2025, 107429
- 2. Yi Zhang, Haitong Zhang, et al. "Study on the mechanism of penetration of particles of air pollution into the brain through the nasal cavity and the potential neurological health risks." Ecotoxicology and Environmental Safety Volume 303, 15 September 2025, 118963
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- 4. Yi Zhang, Zishuo Guo, et al. "Transnasal PLGA Nanoparticles with Terpene Permeation Enhancers: Membrane Remodeling and Tight Junction Modulation for Enhanced Brain Drug Delivery." Int J Mol Sci. 2025 Apr 18;26(8):3861 PMID: 40332504
- 5. Yushi Liu, Jiawen Song, et al. "Synergistic therapy with celastrol-curcumin multifunctional nanomedicine: Anti-hepatocellular carcinoma and reduced hepatotoxicity." Int J Pharm. 2025 Feb 25:671:125289 PMID: 39880142
- 6. Jundong Lin, Xiaoxia Cai, et al. "Fluorescent Nanoparticles Achieve Efficient Photothermal Conversion and Enhanced Antitumor Efficacy Through Intermolecular Aggregation-Caused Quenching" Aggregate. 19 December 2024
| Storage | Store at -20°C |
| M.Wt | 318.86 |
| Cas No. | 50-53-3 |
| Formula | C17H19ClN2S |
| Solubility | ≥45.6 mg/mL in DMSO; ≥48.9 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine |
| SDF | Download SDF |
| Canonical SMILES | CN(C)CCCN1c(cc(cc2)Cl)c2Sc2c1cccc2 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
