CH 223191
Catalog No.
A8609
AhR antagonist
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CH 223191 (CAS 301326-22-7) is an antagonist of the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor involved in mediating the toxic effects associated with dioxins such as TCDD. CH 223191 potently inhibits AhR-mediated transcriptional activation induced by TCDD, exhibiting an IC?? of approximately 30 nM in cell-based assays. In vivo treatment with CH 223191 reduced hepatic cytochrome P450 1A1 expression and mitigated TCDD-induced toxic effects, such as elevated plasma AST and ALT levels and weight loss, indicating its utility as a tool compound for investigating AhR signaling pathways and dioxin toxicity.
- 1. Lin Guo, Jia Zhang, et al. "3,3′-diindolylmethane induces ferroptosis and inhibits proliferation in non-small-cell lung cancer through the AHR/NRF2/GPX4 axis." Discov Oncol. 2025 Mar 18;16(1):344 PMID: 40100489
- 2. Chao Shen, Jing He, et al. "Mepanipyrim induces cardiotoxicity of zebrafish (Danio rerio) larvae via promoting AhR-regulated COX expression pathway." PMID: 36375947
- 3. Chao Shen, Yimei Cai, et al. "Mepanipyrim induces visual developmental toxicity and vision-guided behavioral alteration in zebrafish larvae." PMID: 36182181
- 4. Xiyu Ge, Karen Weis, et al. "Prenatal exposure to the phthalate DEHP impacts reproduction-related gene expression in the pituitary." Reprod Toxicol. 2021 Dec 22;108:18-27. PMID: 34954075
- 5. Yan-Yang Li, Xiao-Jing Wang, et al. "Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s." FASEB J. 2021 Nov;35(11):e21998. PMID: 34669985
- 6. Chang Liu, Yanyang Li, et al. "Baicalein Restores the Balance of Th17/Treg Cells via Aryl Hydrocarbon Receptor to Attenuate Colitis." Mediators Inflamm. 2020 Oct 5;2020:5918587. PMID:30876927
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 333.39 |
Cas No. | 301326-22-7 |
Formula | C19H19N5O |
Solubility | ≥33.3 mg/mL in DMSO; insoluble in H2O; ≥2.31 mg/mL in EtOH |
Chemical Name | 2-methyl-N-[2-methyl-4-[(2-methylphenyl)diazenyl]phenyl]pyrazole-3-carboxamide |
SDF | Download SDF |
Canonical SMILES | CC1=CC=CC=C1N=NC2=CC(=C(C=C2)NC(=O)C3=CC=NN3C)C |
Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure

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