CAY10465
CAY 10465 is a selective, high-affinity aryl hydrocarbon receptor (AhR) agonist with a Ki value of 0.2 nM, and has no activity on the estrogen receptor (Ki>100000 nM) [1]. CAY 10465 (0.01 nM-100 μM) reduces apolipoprotein A-I (apo A-I) levels in HepG2 cells and inhibits protein synthesis [2].
References:
[1]. de Medina P, Casper R, Savouret JF, Poirot M. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91. doi: 10.1021/jm0498194. PMID: 15634023.
[2]. Naem E, Alcalde R, Gladysz M, Mesliniene S, Jaimungal S, Sheikh-Ali M, Haas MJ, Wong NC, Mooradian AD. Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia. Life Sci. 2012 Jul 26;91(1-2):64-9. doi: 10.1016/j.lfs.2012.06.002. Epub 2012 Jun 19. PMID: 22727790.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 317.13 |
| Cas No. | 688348-33-6 |
| Formula | C15H9Cl2F3 |
| Solubility | ≥32.4 mg/mL in DMSO |
| Chemical Name | (E)-1,3-dichloro-5-(4-(trifluoromethyl)styryl)benzene |
| Canonical SMILES | FC(C1=CC=C(/C=C/C2=CC(Cl)=CC(Cl)=C2)C=C1)(F)F |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
