Berbamine hydrochloride
Catalog No.
N2471
Anticancer drug,novel inhibitor of NF-κB activity
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Berbamine hydrochloride (CAS: 6078-17-7) is an isoquinoline alkaloid derivative isolated from plants of the Berberidaceae family. It exerts its biological effects primarily through modulation of various signaling pathways, including inhibition of STAT3 activation and disruption of calcium homeostasis in cells. Berbamine hydrochloride has been investigated for its ability to suppress proliferation and induce apoptosis in multiple cancer cell types, as well as for its immunomodulatory properties. It is widely used in studies exploring mechanisms of tumorigenesis and evaluating potential therapeutic strategies in cancer and immune-related research.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 681.65 |
| Cas No. | 6078-17-7 |
| Formula | C37H42Cl2N2O6 |
| Solubility | ≥68 mg/mL in DMSO; ≥10.68 mg/mL in H2O; ≥4.57 mg/mL in EtOH |
| Chemical Name | (11S,31R)-16,36,37-trimethoxy-12,32-dimethyl-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphan-54-ol dihydrochloride |
| Canonical SMILES | COC1=C2C3=C(CCN([C@]3([H])CC4=CC=C(O)C(OC5=CC=C(C[C@@]6([H])C7=CC(O2)=C(C=C7CCN6C)OC)C=C5)=C4)C)C=C1OC.Cl.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | Berbamine hydrochloride is the next generation anticancer drug with IC50 values of 5.83 μg/ml (24h) and 34.5 µM for KU812 and HepG2 cells, respectively. | |||||
| Targets | KU812 | HepG2 | MCF-7/ADR | KBv200 | K562 | |
| IC50 | 5.83 μg/ml (24h) | 34.5 µM | ||||
Quality Control & MSDS
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Chemical structure
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