AMG 9810
Catalog No.
B7018
TRPV1 antagonist
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AMG 9810 (CAS 545395-94-6) is a competitive antagonist of transient receptor potential vanilloid type 1 (TRPV1), acting by blocking activation induced by capsaicin, protons, heat, and endogenous ligands such as N-arachidonoyldopamine and oleoyldopamine. AMG 9810 demonstrates nanomolar potency against human and rat TRPV1, effectively inhibiting capsaicin-induced Ca2? influx and calcitonin gene-related peptide (CGRP) release in cultured rat dorsal root ganglion neurons. In rodent models, AMG 9810 reduces capsaicin-triggered physiological responses, notably ocular irritation, highlighting its utility for investigating TRPV1-related pain and sensory signal pathways.
| Storage | Store at -20°C |
| M.Wt | 337.41 |
| Cas No. | 545395-94-6 |
| Formula | C21H23NO3 |
| Solubility | ≥33.7 mg/mL in DMSO; insoluble in H2O; ≥2.55 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | (E)-3-(4-(tert-butyl)phenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide |
| SDF | Download SDF |
| Canonical SMILES | CC(C)(C)c1ccc(/C=C/C(Nc(cc2)cc3c2OCCO3)=O)cc1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
