4-Thiouridine
Catalog No.
C3722
4-Thiouridine is a ribonucleoside analog that is widely utilized in RNA analysis and (m)RNA labeling. It also inhibits rRNA synthesis, leading to a nucleolar stress response.
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4-Thiouridine (CAS 13957-31-8) is a thiol-substituted ribonucleoside analog commonly utilized in RNA research for photoactivatable labeling and RNA cross-linking experiments. Structurally, 4-thiouridine differs from natural uridine solely by the substitution of a sulfur atom at the 4-position of the nucleotide base. Due to this close structural similarity, it integrates into RNA sequences with minimal disruption, preserving typical base-pairing properties and RNA functionality. Upon UV irradiation, the incorporated thiol group induces covalent short-range RNA–RNA cross-links, facilitating detailed analysis of RNA interactions, turnover rates, and dynamics within cellular contexts.
- 1. Dan Zhao, Lu Zhang, et al. "Transcriptome dynamics in mouse amygdala under acute and chronic stress revealed by thiol-labeled RNA sequencing." Neurobiol Stress. 2024 Nov 7:33:100688
- 2. Haoqing Yang, Wanqing Wang, et al. "miR615‐3p inhibited FBLN1 and osteogenic differentiation of umbilical cord mesenchymal stem cells by associated with YTHDF2 in a m6A‐miRNA interaction manner." Cell Prolif. 2024 Jun;57(6):e13607 PMID: 38353178
- 3. Luyuan Jin, et al. "miR615-3p inhibited FBLN1 and osteogenic differentiation of umbilical cord mesenchymal stem cells by associated with YTHDF2 in a m6A-miRNA interaction manner." Cell Prolif. 2024 Feb 14:e13607. PMID: 38353178
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 260.26 |
| Cas No. | 13957-31-8 |
| Formula | C9H12N2O5S |
| Solubility | ≥107.8 mg/mL in DMSO; ≥25.85 mg/mL in EtOH; ≥44.8 mg/mL in H2O |
| Chemical Name | 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-thioxo-3,4-dihydropyrimidin-2(1H)-one |
| SDF | Download SDF |
| Canonical SMILES | OC[C@H]([C@H]([C@H]1O)O)O[C@H]1N(C=CC(N1)=S)C1=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
