1-Stearoyl-2-lyso-sn-glycero-3-PC

1-Stearoyl-2-lyso-sn-glycero-3-PC (CAS No.: 19420-57-6) is a saturated lysophosphatidylcholine (LPC) and a biologically relevant phospholipid derivative characterized by a single acyl chain, widely utilized as a biochemical reagent in membrane biology and lipid metabolism research. As a member of the LPC family, it modulates membrane physicochemical properties, including fluidity and permeability, thereby influencing membrane protein function, lipid–protein interactions, and intracellular signaling pathways. Functionally, this molecule has been shown to regulate inflammatory and oncogenic signaling, including inhibition of histone deacetylase 3 activity and suppression of STAT3 phosphorylation in leukemia cell models, leading to apoptosis and antiproliferative effects in chronic myelogenous leukemia cells. In immune contexts, it can enhance pro-inflammatory cytokine production such as IL-1β in primary human monocytes at low micromolar concentrations, supporting its role in immune modulation and inflammatory signaling. Altered endogenous levels of related LPC species have been associated with pathological states, including cancer, highlighting its relevance in disease-related lipidomics. In vitro, its biological activity is typically observed in the low micromolar range, although effective concentrations vary depending on cell type and assay conditions. This compound is commonly applied in studies of phospholipase activity, lipid signaling pathways, apoptosis mechanisms, and membrane dynamics, as well as in cell-based assays to investigate physiological and pathological responses, with experimental dosing tailored to specific research objectives.