Tiplaxtinin(PAI-039)
Catalog No.
B5906
Orally efficacious inhibitor of PAI-1
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Tiplaxtinin (PAI-039; CAS 393105-53-8) is an orally bioavailable small molecule inhibitor targeting plasminogen activator inhibitor-1 (PAI-1), a physiological regulator of the plasminogen activation system. Elevated PAI-1 levels stabilize thrombi by inhibiting tissue- and urokinase-type plasminogen activators. Tiplaxtinin binds selectively to PAI-1 with a Kd of approximately 480 nM and inhibits its activity with an IC50 value around 2.7 μM. In animal models, oral administration of Tiplaxtinin significantly delayed arterial thrombus-induced occlusion, supporting its utility as a research tool for studying fibrinolytic pathways and thrombotic disorders.
- 1. Mantong Zhao, Lina Hu, et al. "Plasminogen Activator Inhibitor 1 Controls Abdominal Aortic Aneurism Formation via the Modulation of." FASEB J. 2025 May 15;39(9):e70562. PMID: 40323694
- 2. Danhui Liu, Yuzhen Liu, et al. "Trichostatin A promotes esophageal squamous cell carcinoma cell migration and EMT through BRD4/ERK1/2-dependent pathway." Cancer Med. 2021 Aug;10(15):5235-5245. PMID: 34160902
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 439.38 |
| Cas No. | 393105-53-8 |
| Formula | C24H16F3NO4 |
| Solubility | insoluble in H2O; ≥17.6 mg/mL in DMSO; ≥53.7 mg/mL in EtOH |
| Chemical Name | 2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indol-3-yl)-2-oxoacetic acid |
| SDF | Download SDF |
| Canonical SMILES | OC(C(c1c[n](Cc2ccccc2)c(cc2)c1cc2-c(cc1)ccc1OC(F)(F)F)=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
