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Tigecycline hydrochloride

Catalog No.
B1219
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First-in-class, broad spectrum antibiotic
Grouped product items
SizePriceStock Qty
10mg
$142.00
Ship with 10-15 days
50mg
$348.00
Ship with 10-15 days
100mg
$595.00
Ship with 10-15 days
200mg
$860.00
Ship with 10-15 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Tigecycline hydrochlorideis a first-in-class, broad spectrum antibiotic with activity against antibiotic-resistant organisms.

Chemical Properties

StorageStore at -20°C
M.Wt622.11
Cas No.197654-04-9
FormulaC29H40ClN5O8
SolubilitySoluble in DMSO
Chemical Name(4S,4aS,5aR,12aS)-9-((Z)-(2-(tert-butylamino)-1-hydroxyethylidene)amino)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carbimidic acid hydrochloride
SDFDownload SDF
Canonical SMILESCC(C)(NC/C(O)=N/C1=CC(N(C)C)=C(C2=C1O)C[C@@](C(C2=O)=C(O)[C@@]34O)([H])C[C@@]3([H])[C@@](N(C)C)([H])C(O)=C(C(O)=N)C4=O)C.Cl
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment [1]:

Cell lines

Human leukemic cell culture

Preparation method

The solubility of this compound in DMSO is soluble. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

0.63-30 µM

Applications

The results showed that tigecycline had the ability to inhibit mitochondrial translation as it had in vitro and in vivo activity against acute myeloid leukemia (AML). Tigecycline was relatively unstable after reconstruction, and this instability might limit the use of the drug to treat infections in ambulatory infusions and prevent the development of optimal dosage regimens for AML.
Animal experiment [1]:

Animal models

NOD / SCID mice model of acute myeloid leukemia (AML) xenograft

Dosage form

50mg/kg (i.p.), twice daily for 11 days

Application

Both tigecycline and the new formulation reduced tumor volume and weight with similar efficacy.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Jitkova Y, Gronda M, Hurren R, Wang X, Goard CA, Jhas B, Schimmer AD. A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity. PLoS One. 2014 May 28;9(5):e95281. doi: 10.1371/journal.pone.0095281. eCollection 2014. PubMed PMID: 24871339; PubMed Central PMCID: PMC4037176.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Tigecycline hydrochloride