STM2457
Catalog No.
B8750
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STM2457 (CAS 2499663-01-1) is an orally bioavailable small-molecule inhibitor targeting the catalytic activity of METTL3, an enzyme involved in mRNA N6-methyladenosine (m^6A) modification. STM2457 demonstrates potent inhibitory activity in vitro, with an IC50 of 16.9 nM against METTL3. Given the significance of METTL3-mediated m^6A modification in cancer pathogenesis, particularly acute leukemia, STM2457 serves as a valuable research tool for investigating METTL3-associated biological processes, disease mechanisms, and therapeutic potential.
| Storage | Store at -20°C |
| M.Wt | 444.54 |
| Cas No. | 2499663-01-1 |
| Formula | C25H28N6O2 |
| Solubility | ≥10.6 mg/mL in DMSO; ≥26.8 mg/mL in EtOH; insoluble in H2O |
| Chemical Name | N-((5-(((cyclohexylmethyl)amino)methyl)-3aH-benzo[d]imidazol-2-yl)methyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | O=C(C(N=C1N2C=CC=C1)=CC2=O)NCc1nc(ccc(CNCC2CCCCC2)c2)c2[nH]1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
