PD-1/PD-L1 inhibitor 1
Catalog No.
B6172
PD-1/PD-L1 interaction inhibitor
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PD-1/PD-L1 inhibitor 1 (CAS: 1675201-83-8) is a small molecule inhibitor targeting the interaction between programmed cell death protein 1 (PD-1) and its ligand PD-L1. By disrupting PD-1/PD-L1 signaling, this agent restores and enhances T-cell activation, demonstrating immunomodulatory properties. In vitro assays (HTRF binding assay) report IC50 values ranging from 6 to 100 nM. Current preclinical evidence positions PD-1/PD-L1 inhibitor 1 as a candidate compound for studying tumor immunity and infectious diseases, such as hepatitis C virus infection.
| Storage | Store at -20°C |
| M.Wt | 475.58 |
| Cas No. | 1675201-83-8 |
| Formula | C29H33NO5 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥5.98 mg/mL in DMSO with gentle warming and ultrasonic |
| Chemical Name | (S)-1-(2,6-dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | O=C([C@H]1N(CC2=C(OC)C=C(OCC3=CC=CC(C4=CC=CC=C4)=C3C)C=C2OC)CCCC1)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
