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Nortadalafil

Catalog No.
A3665
PDE5 inhibitor
Grouped product items
SizePriceStock Qty
2mg
$84.00
In stock
5mg
$117.00
In stock
10mg
$183.00
In stock
50mg
$525.00
Ship with 10-15 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Nortadalafil (CAS 171596-36-4) is a demethylated analogue of tadalafil, a selective inhibitor of phosphodiesterase type 5 (PDE5). PDE5 selectively hydrolyzes cyclic GMP (cGMP) within the corpus cavernosum, modulating vasodilation essential for penile erection. By inhibiting PDE5, nortadalafil contributes to sustained cGMP-dependent signal transduction, thus enhancing nitric oxide-mediated vasodilation pathways. Tadalafil displays potent inhibition of PDE5 with an IC50 of approximately 5 nM and marked selectivity over other PDE isoforms (PDE1–4, PDE6). Nortadalafil serves as an analytical reference for pharmacological and biochemical studies on PDE5 inhibitors in erectile dysfunction and pulmonary arterial hypertension research.

Chemical Properties

StorageStore at -20°C
M.Wt375.38
Cas No.171596-36-4
FormulaC21H17N3O4
SynonymsDemethyl Tadalafil
Solubility≥32.7 mg/mL in DMSO; ≥2.32 mg/mL in EtOH with ultrasonic; insoluble in H2O
Chemical Name(6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione
SDFDownload SDF
Canonical SMILESO=C1N([H])C([H])([H])C(N2[C@@](C(C([H])=C3[H])=C([H])C4=C3OC([H])([H])O4)([H])C(N([H])C5=C([H])C([H])=C([H])C([H])=C65)=C6C([H])([H])[C@@]21[H])=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Biological Activity

Description Nortadalafil is a inhibitor of PDE5.
Targets PDE5          
IC50            

Quality Control