Nintedanib esylate
Catalog No.
C6370
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Nintedanib esylate (BIBF 1120 esylate) is a small-molecule tyrosine kinase inhibitor that simultaneously inhibits the tyrosine kinase activity of vascular endothelial growth factor receptors (VEGFR1/2/3), fibroblast growth factor receptors (FGFR1/2/3), and platelet-derived growth factor receptors (PDGFRα/β). The in vitro IC50 values are approximately 13-34 nM for VEGFR, 37-108 nM for FGFR, and 59-65 nM for PDGFR, respectively. This compound is mainly used for research on anti-angiogenesis-related mechanisms and has broad applications in tumor and fibrotic disease model studies.
| Storage | Store at -20°C |
| M.Wt | 649.76 |
| Cas No. | 656247-18-6 |
| Formula | C33H39N5O7S |
| Synonyms | BIBF 1120 esylate |
| Solubility | ≥26.15 mg/mL in DMSO; ≥2.65 mg/mL in EtOH gentle warming and ultrasonic; ≥17.17 mg/mL in H2O |
| Chemical Name | (Z)-methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate |
| SDF | Download SDF |
| Canonical SMILES | O=C(OC)C1=CC(NC2=O)=C(/C2=C(C3=CC=CC=C3)/NC4=CC=C(N(C(CN5CCN(CC5)C)=O)C)C=C4)C=C1.CCS(=O)(O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
