Nicotinamide Riboside Chloride (NIAGEN)
Nicotinamide Riboside Chloride (NIAGEN; CAS 23111-00-4) is a small molecule precursor of nicotinamide adenine dinucleotide (NAD+), an essential cofactor implicated in energy metabolism and cellular homeostasis. Upon oral administration, it effectively elevates intracellular NAD+ levels, subsequently modulating the activity of NAD+-dependent sirtuin enzymes, particularly SIRT1 and SIRT3. Experimental evidence indicates that Nicotinamide Riboside Chloride enhances oxidative metabolism and mitigates metabolic dysfunction induced by high-fat dietary conditions. Additionally, studies employing Alzheimer's disease transgenic mouse models suggest that this compound can reduce cognitive decline, supporting its use in biomedical research targeting metabolic and neurodegenerative conditions.
| Storage | Store at 4°C, protect from light |
| M.Wt | 290.7 |
| Cas No. | 23111-00-4 |
| Formula | C11H15ClN2O5 |
| Solubility | ≥22.75 mg/mL in DMSO; ≥3.63 mg/mL in EtOH with ultrasonic; ≥42.8 mg/mL in H2O |
| Chemical Name | 3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride |
| SDF | Download SDF |
| Canonical SMILES | NC(C1=C[N+]([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)=CC=C1)=O.[Cl-] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
