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KU14R

Catalog No.
A3534
I(3)-R antagonist
Grouped product items
SizePriceStock Qty
10mg
$164.00
Ship with 5-10 days
50mg
$702.00
Ship with 5-10 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

A new I(3)-R antagonist, KU14R (2 (2-ethyl 2,3-dihydro-2-benzofuranyl)-2-imidazole), which selectively blocks the insulin secretory response to imidazolines. KU14R partially attenuated responses to Imidazole-4-acetic acid-ribotide (IAA-RP). The effects of KU14R on stimulus secretion-coupling in normal mouse islets and beta cells was compared by measuring KATP channel activity, plasma membrane potential, cytosolic calcium concentration ([Ca2+]c) and dynamic insulin secretion. In the presence of 10 mmol/l but not of 5 mmol/l glucose, KU14R (30, 100 or 300 micromol/l) was ineffective. KATP channel was blocked by KU14R (IC50 31.9 micromol/l, Hill slope -1.5). KU14R does not act as an antagonist of either efaroxan or S22068 at an imidazoline site in vivo.

Chemical Properties

Physical AppearanceWhite solid
StorageStore at -20°C
M.Wt214.26
Cas No.189224-48-4
FormulaC13H14N2O
SynonymsKU-14R;KU 14R
SolubilitySoluble in DMSO
Chemical Name2-(2-ethyl-2,3-dihydrobenzofuran-2-yl)-1H-imidazole
SDFDownload SDF
Canonical SMILESCCC1(C2=NC=CN2)CC3=CC=CC=C3O1
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

KU14R