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IRAK inhibitor 1

Catalog No.
A3500
IRAK-4 inhibitor
Grouped product items
SizePriceStock Qty
5mg
$225.00
In stock
10mg
$307.00
In stock
50mg
$378.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

IC50: 35 nM for IRAK-4

The interleukin-1 receptor associated kinase (IRAK) family is comprised of four family members IRAK-1, IRAK-2, IRAK-3/M, and IRAK-4. Upon activation of their upstream cognate receptors, IRAK-4 is thought to phosphorylate IRAK-1 resulting in the activation and autophosphorylation of IRAK-1 an subsequent phosphorylation of downstream substrates. IRAK inhibitor 1 is an inhibitor of interleukin-1 receptor associated kinase 4 (IRAK-4).

In vitro: The regioisomeric pyridines IRAK inhibitor 1 (6) and it analogue (7) showed contrasting SAR, with the 2,6-pyridine isomer IRAK inhibitor 1 having low-nanomolar potency whilst the 2,4-pyridine isomer 7 showed little activity, despite having a more accessible bidentate-binding motif. At 10 μM, IRAK inhibitor 1 was found to have 39% inhibition for JNK-1 and 15% inhibition for JNK-2, respectivley [1].

In vivo: No animal in-vivo data available currently IRAK inhibitor 1 and its analogues.

Clinical trial: IRAK inhibitor 1 is currently in the preclinical development stage and no clinical data are available.

Reference:
[1] Buckley GM, Ceska TA, Fraser JL, Gowers L, Groom CR, Higueruelo AP, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD, Sabin V.   IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding. Bioorg Med Chem Lett. 2008;18(11):3291-5.

Product Citation

Chemical Properties

StorageStore at -20°C
M.Wt293.37
Cas No.1042224-63-4
FormulaC17H19N5
Solubilityinsoluble in EtOH; insoluble in H2O; ≥14.4 mg/mL in DMSO
Chemical Name6-imidazo[1,2-a]pyridin-3-yl-N-piperidin-4-ylpyridin-2-amine
SDFDownload SDF
Canonical SMILESC1CNCCC1NC2=CC=CC(=N2)C3=CN=C4N3C=CC=C4
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Biological Activity

Description IRAK inhibitor 1 is an inhibitor of interleukin-1 receptor associated kinase 4 (IRAK-4).
Targets IRAK-4          
IC50            

Quality Control

Chemical structure

IRAK inhibitor 1

Related Biological Data

IRAK inhibitor

Related Biological Data

IRAK inhibitor