EG00229
Catalog No.
B4657
Nrp1 inhibitor
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EG00229 (CAS 1210945-69-9) is a small molecule inhibitor targeting neuropilin-1 (Nrp1). It disrupts the binding between vascular endothelial growth factor-A (VEGF-A) and the Nrp1 receptor, inhibiting interactions involving purified Nrp1, and Nrp1-expressing PAE cells, with IC50 values of approximately 3 μM and 8 μM, respectively. EG00229 also inhibits VEGF-A interaction with Nrp1, VEGFR1, and VEGFR2 in human umbilical vein endothelial cells (HUVECs). Additionally, it impairs tuftsin-mediated activation of Nrp1, consequently blocking tuftsin-induced anti-inflammatory M2 polarization in microglia. This compound is valuable for investigating Nrp1's role in angiogenesis and inflammation.
- 1. Sean J Miller, Rahul M Dhodapkar, et al. "SARS-CoV-2 induces Alzheimer's disease–related amyloid-β pathology in ex vivo human retinal explants." Sci Adv. 2025 Jul 4;11(27):eads5006 PMID: 40614201
- 2. Jingjing Zhang, Jinxin Qiu, et al. "Neuropilin-1 mediates lung tissue-specific control of ILC2 function in type 2 immunity." Nat Immunol. 2022 Feb;23(2):237-250. PMID: 35075279
| Storage | Store at -20°C |
| M.Wt | 611.6 |
| Cas No. | 1210945-69-9 |
| Formula | C19H20F3N7O7S3 |
| Solubility | ≥26.25 mg/mL in DMSO; ≥3.52 mg/mL in EtOH with ultrasonic; insoluble in H2O |
| Chemical Name | (S,Z)-2-(((3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)thiophen-2-yl)(hydroxy)methylene)amino)-5-guanidinopentanoic acid compound with 2,2,2-trifluoroacetic acid (1:1) |
| SDF | Download SDF |
| Canonical SMILES | N=C(NCCC[C@@](/N=C(O)/C1=C(NS(C2=CC=CC3=NSN=C32)(=O)=O)C=CS1)([H])C(O)=O)N.FC(F)(F)C(O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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