CFTR corrector 2
CFTR corrector 2 (CAS No.: 1628416-28-3) is a small-molecule cystic fibrosis transmembrane conductance regulator (CFTR) corrector identified from patent-derived chemical series and widely used as a biochemical tool in cystic fibrosis research. It functions by modulating CFTR protein conformational maturation and enhancing its stability, thereby promoting improved folding, intracellular trafficking, and localization of the channel to the cell membrane. Through these mechanisms, CFTR corrector 2 facilitates restoration of CFTR channel activity in vitro, making it valuable for investigating protein misfolding and quality control pathways associated with CFTR dysfunction. Activity has generally been observed in the nanomolar to micromolar concentration range in cell-based assays, although precise potency can vary depending on the experimental system and mutation context. This compound is commonly applied in cellular models expressing defective CFTR variants, as well as in broader studies of proteostasis, ion channel regulation, and compound screening workflows aimed at identifying modulators of CFTR processing. Experimental concentrations and treatment regimens are typically optimized according to specific assay conditions and research objectives.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 486.50 |
| Cas No. | 1628416-28-3 |
| Formula | C27H23FN4O4 |
| Solubility | ≥10.98 mg/mL in DMSO with ultrasonic; ≥4.76 mg/mL in EtOH with ultrasonic; insoluble in H2O |
| Chemical Name | 2-(7-ethoxy-4-(3-fluorophenyl)-1-oxophthalazin-2(1H)-yl)-N-methyl-N-(2-methylbenzo[d]oxazol-6-yl)acetamide |
| Canonical SMILES | O=C(N(C)C1=CC=C(N=C(C)O2)C2=C1)CN(C3=O)N=C(C4=CC=CC(F)=C4)C5=C3C=C(OCC)C=C5 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |