AZD0156
AZD0156 (CAS number: 1821428-35-6) is an orally bioavailable, potent and selective small-molecule inhibitor of ataxia telangiectasia mutated (ATM) kinase, a serine/threonine kinase within the phosphatidylinositol 3-kinase-related kinase (PIKK) family. ATM kinase contributes critically to DNA damage response signaling activated by DNA double-strand breaks, thus facilitating DNA repair, checkpoint control, genomic stability, and cell fate decisions. AZD0156 demonstrates sub-nanomolar inhibitory potency against cellular ATM signaling and exhibits over 1000-fold selectivity relative to other PIKK enzymes. In preclinical models, oral AZD0156 administration potentiates antitumor responses induced by double-strand break-generating agents. Currently, AZD0156 is undergoing early clinical trials assessing safety and preliminary efficacy for advanced cancers.
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| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 461.56 |
| Cas No. | 1821428-35-6 |
| Formula | C26H31N5O3 |
| Solubility | ≥23.1 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥5.49 mg/mL in EtOH |
| Chemical Name | 8-(6-(3-(dimethylamino)propoxy)pyridin-3-yl)-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-2(3H)-one |
| SDF | Download SDF |
| Canonical SMILES | O=C(N1C2CCOCC2)N(C)C3=C1C4=CC(C5=CC=C(OCCCN(C)C)N=C5)=CC=C4N=C3 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
Related Biological Data
Related Biological Data
