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Amikacin

Catalog No.
B3431
aminoglycoside antibiotic
Grouped product items
SizePriceStock Qty
1g
$65.00
In stock
5g
$260.00
Ship with 10-15 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Amikacin(BAY416651) is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt585.6
Cas No.37517-28-5
FormulaC22H43N5O13
Solubilityinsoluble in EtOH; insoluble in DMSO; ≥5.86 mg/mL in H2O
Chemical Name(2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide
SDFDownload SDF
Canonical SMILESC1C(C(C(C(C1NC(=O)C(CCN)O)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)O)N
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Protocol

Cell experiment [1]:

Cell lines

Klebsiella pneumoniae

Preparation method

The solubility of this compound in DMSO is < 5.86mg/ml. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

Applications

Of all Ags, amikacin (Ak) is the most resistant to the action of Ag-modifying enzymes. However, AAC (6')-I type enzymes (a group of 6'-N-acetyltransferases) can utilize Ak as substrate and confer resistance to this antibiotic in addition to other Ags.

References:

[1]. Tolmasky ME. Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm. Front Biosci. 2000 Jan 1;5: D20-9. Review. PubMed PMID: 10702385.

Quality Control