7,8-Dihydroxyflavone
Catalog No.
B5484
Tyrosine kinase receptor B (TrkB) agonist
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7,8-Dihydroxyflavone (Tropoflavin, CAS: 38183-03-8) is a selective agonist of the tropomyosin receptor kinase B (TrkB).It activates TrkB-mediated signaling pathways, resulting in enhanced neuronal survival and modulation of synaptic plasticity. 7,8-Dihydroxyflavone is widely utilized in experimental studies on neurodegenerative diseases and neurological disorders, serving as a valuable tool for investigating neurotrophic signaling mechanisms and the development of potential therapeutics for central nervous system pathologies.
- 1. Junxi Fu, Wentian Song, et al. "Synergistic Effect of Combined Walnut Peptide and Ginseng Extracts on Memory Improvement in C57BL/6 Mice and Potential Mechanism Exploration." Foods. 2023 Jun 9;12(12):2329. PMID: 37372540
- 2. Li Yaqun, Yuan Haixia, et al. "An Shen Ding Zhi Ling Ameliorates the Symptoms of Attention Deficit Hyperactivity Disorder via Modulating Brain-Derived Neurotrophic Factor-Related Signaling Pathways." Evid Based Complement Alternat Med. 2022 Jul 21;2022:5471586. PMID: 35911131
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 254.24 |
| Cas No. | 38183-03-8 |
| Formula | C15H10O4 |
| Solubility | insoluble in H2O; ≥12.75 mg/mL in DMSO; ≥2.99 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | 7,8-dihydroxy-2-phenyl-4H-chromen-4-one |
| SDF | Download SDF |
| Canonical SMILES | Oc(ccc1c2OC(c3ccccc3)=CC1=O)c2O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
Related Biological Data
