ZD 7288
Catalog No.
B6542
HCN channel inhibitor
Featured Products
ZD 7288 (CAS 133059-99-1) is a selective inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. These channels mediate Na^+ and K^+ currents, notably the hyperpolarization-activated current (I_h), contributing to neuronal excitability and rhythmic activity. ZD 7288 reduces I_h in a concentration-dependent, voltage- and time-sensitive manner, as demonstrated in rat facial motoneurons (IC_50 ~0.2 μM) and hippocampal CA1 pyramidal neurons. Additionally, it inhibits T-type calcium currents in rat CA1 pyramidal cells. ZD 7288 is utilized in research investigating neuronal excitability mechanisms, pain signaling, and chronic visceral pain models.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 292.81 |
| Cas No. | 133059-99-1 |
| Formula | C15H21ClN4 |
| Solubility | Soluble in DMSO |
| Chemical Name | (E)-N-ethyl-1,2-dimethyl-6-(methylimino)-N-phenyl-1,6-dihydropyrimidin-4-amine hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CCN(C1=CC=CC=C1)C2=C/C(N(C)C(C)=N2)=N\C.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
