Vindesine sulfate

Vindesine sulfate (CAS No.: 59917-39-4) is a vinca alkaloid antimitotic research compound, described as a semisynthetic derivative within the vinblastine related scaffold and historically associated with alkaloid lineage from Catharanthus roseus, and it is primarily categorized in oncology focused cell biology and cytoskeleton pharmacology as a tubulin targeting agent that binds microtubular proteins of the mitotic spindle, disrupts microtubule dynamics, promotes microtubule crystallization like behavior, and induces mitotic arrest with downstream loss of proliferative capacity and cell death phenotypes in dividing cell populations; available experimental summaries indicate potent biochemical engagement of tubulin with reported inhibitory affinity in the submicromolar domain and antiproliferative effects observed in vitro generally spanning nanomolar to micromolar concentration ranges depending on model system, exposure schedule, and assay endpoint, while in vivo preclinical studies in animal tumor biology settings have been used to examine antitumor like pharmacology at protocol dependent dose levels, making this molecule a relevant tool for mechanistic studies of M phase control, spindle assembly checkpoint stress, and cytoskeletal vulnerability profiling, as well as for comparative compound screening workflows where concentrations or doses used in experiments typically depend on specific experimental designs and research objectives.